The dataset includes the draft main paper and supporting information file to be submitted to the journal, and also excel spread sheets containing the raw data which backs up the processed data used in the paper and supporting information file. Data include exposure characterization (temperature, RH, pollutant levels, etc.), physiology data, serum data, lung inflammation data, viral burden data, PCR data, blood data, lung pathology data, and other miscellaneous data. All the column headings and other relevant definitions and information are included in the data sets, and match the relevant data in the paper to be submitted. This dataset is associated with the following publication: Hargrove, M., S. Snow, R. Luebke, C. Wood, J. Krug, T. Krantz, C. King, C. Copeland, S. McCullough, K. Gowdy, U. Kodavanti, I. Gilmour, and S. Gavett. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(5): 3062-3070, (2018).