Non-confidential information on the manufacture, import, processing, and use of chemicals in commerce at national and regional levels Internet Archive URL: https://web.archive.org/web/*/https://epa.gov/chemical-data-reporting/2012-chemical-data-reporting-results

This is a collection of over 290,000 hazard data records compiled for the Alternatives Assessment Dashboard. The hazard data includes records for human health, ecotoxicity, and fate. The human health records include records for Acute mammalian toxicity, Carcinogenicity, Mutagenicity, Endocrine disruption, Reproductive toxicity, Developmental toxicity, Neurotoxicity, Systemic toxicity, Skin sensitization, Skin irritation, and Eye irritation. The ecotoxicity records include records for acute and chronic aquatic toxicity. The fate records include records for persistance and bioaccumulation. The source of the hazard records include GHS (Globally Harmonized System) hazard codes, hazard categories, quantitative toxicity data, and predicted toxicity data.

This tool is intended to aid individuals interested in learning more about chemicals that are manufactured or imported into the United States. Health and safety information on these chemicals, primarily in the form of paper documents, are routinely submitted by industry (manufacturers or importers of chemicals) to EPA under the Toxic Substances Control Act (TSCA). EPA is in the process of converting these documents into electronic form and making non-confidential versions of these documents accessible through this tool. The tool enables users to conduct both full text and metadata searches of these documents, and presents these as .pdf for viewing or downloading. The tool also queries existing EPA legacy database sources of chemical information and presents these data in a consistent format.

In sechs kleinen bis mittelgrossen Fliessgewässern wurden die für aquatische Organismen extrem toxischen Pyrethroid- und Organophosphatinsektizide mittels einer Spezialanalytik bis in den Picogramm pro-Liter Bereich quantifiziert. An fünf der sechs untersuchten Standorte überschritten die gemessenen Insektizidkonzentrationen regelmässig chronische und zum Teil akute Qualitätskriterien und die chronische Mischungsrisiko¬bewertung zeigte während 43-100% des Untersuchungszeitraums hohe Risiken für die Invertebratengemeinschaft an. Werden Pyrethroid- und Organophosphatinsektizide nicht in die Beurteilung der Gewässerqualität miteinbezogen, kann das Gesamtrisiko für aquatische Organismen erheblich unterschätzt werden.

Data from five laboratory bioassays and three field mesocosm studies performed by Dr. Patrick Moran of the USDA-ARS Invasive Species and Pollinator Health Research Unit, to examine the toxicity of five herbicides (2,4-D, glyphosate, imazamox, penoxsulam and diquat) and two surfactants that are often applied with herbicides (a paraffinic-oil based one and a vegetable oil-based one) to the planthopper Megamelus scutellaris (Hemiptera: Delphacidae) released in the US for biological control of waterhyacinth (Eichhornia crassipes or Pontederia crassipes) an invasive floating aquatic weed. The studies were performed between 2016 and 2021 to support integrated management of waterhyacinth in the Sacramento-San Joaquin Delta of northern California. The planthopper has also been released in Florida and Mississippi, and in South Africa. Herbicide applications are often still necessary where this planthopper and other biocontrol agents have been released. The research question was 'can the planthopper survive exposure to the herbicides and surfactants?'. In lab bioassays, planthoppers from greenhouse colonies were exposed to herbicide-dipped leaves for 24 hours and then allowed to feed for six days on untreated plants. Planthoppers were then collected, frozen and counted. Exposure to diquat or the paraffinic oil-based surfactant caused 40% to 69% greater mortality than did exposure to water-dipped leaves in more than one trial, while the other four herbicides and the vegetable oil-based surfactant were not toxic. In field mesocosm tests, mesocosms were established in 21L tanks caged with mesh tents, and plants allowed to grow for 4 weeks. Between 150 and 240 adult planthoppers were then released into each mesocosm. The following day, mesocosms were sprayed with herbicide, surfactant or insecticide solutions or an insecticide positive control. Three days later, planthoppers were collected with vacuums, frozen and counted. Only treatment with the paraffinic oil-based surfactant reduced final counts (by 36% to 49%) in a manner that was statistically significant compared to water-sprayed mesocosms in more than one mesocosm field trial, along with the insecticide positive control (by up to 98%). Diquat reduced final counts by 64% in one trial. The results indicate that, with the possible exception of diquat, exposing planthoppers to herbicides does not cause significant mortality, consistent with prior regulatory evaluations of these herbicides as being safe for insects. A surfactant that is often applied with the herbicides is toxic to the planthopper, consistent with expectations that this surfactant, designed to break down plant waxes on leaf surfaces, is likely also harmful to insect cuticular waxes, which insects rely on to contain body fluids. Leaving unsprayed refuges for the planthopper may be a useful component of integrated waterhyacinth control programs. Resources in this dataset: Resource Title: Data dictionary for dataset on toxicity of five herbicides and two surfactants towards the planthopper Megamelus scutellaris File Name: Data dictionary for AgPub archive plain text.txt Resource Description: Plain text file providing definition of each column in the data file and further information. Resource Title: Toxicity of herbicides and surfactants to the waterhyacinth planthopper Megamelus scutellaris File Name: Waterhyacinth planthopper herbicide toxicity data PMoran.csv Resource Description: Five herbicides, two surfactants tested, along with a negative control (water exposure) and, in some tests, a positive control (insecticide)

The Drinking Water Treatability Database (TDB) presents referenced information on the control of contaminants in drinking water. It allows drinking water utilities, first responders to spills or emergencies, treatment process designers, research organizations, regulators and others to access referenced information gathered from thousands of literature sources on regulated and unregulated contaminants.

Toxicological data generated for Apis mellifera honey bees and an ectoparasitic mite (Varroa destructor) in laboratory toxicity trials are presented. Data were generated over a four-year period by members of the Varroacide Research and Testing Team (VRTT) as part of a foundational grant from the Foundation for Food and Agricultural Research (FFAR). Data may be used to explore toxicological responses of honey bees and Varroa mites to a wide range of natural and synthetic chemical treatments against Varroa infestations in honey bee colonies. Data may be collected and analyzed together with other data sets not generated by VRTT.

Spectral fits and linear combination data for ZnO and CuO nanoparticles exposure during toxicity testing. This dataset is associated with the following publication: Ivask, A., K. Scheckel, P. Kapruwan, V. Stone, H. Yin, N. Voelcker, and E. Lombi. Complete transformation of ZnO and CuO nanoparticles in culture medium and lymphocyte cells during toxicity testing. Prof. Hakan Wallin, and Dr. Alison Elder Nanotoxicology. Informa Healthcare, London, UK, 11(2): 150-156, (2017).

The Toxics Release Inventory (TRI) Chemical Hazard Information Profiles (TRI-CHIP) dataset contains hazard information about the chemicals reported in TRI. Users can use this XML-format dataset to create their own databases and hazard analyses of TRI chemicals. The hazard information is compiled from a series of authoritative sources including the Integrated Risk Information System (IRIS). The dataset is provided as a downloadable .zip file that when extracted provides XML files and schemas for the hazard information tables.